This talk presents an overview and update of PySAL. PySAL is designed to support the development of high level applications in exploratory spatial data analysis and geocomputation. The library includes a comprehensive suite of modules that cover the entire spatial data analysis research stack from geospatial data processing and integration, to exploratory spatial data analysis, spatial dynamics, regionalization, and spatial econometrics. A selection of these modules are illustrated drawing on research in spatial criminology, epidemiology and urban inequality dynamics. A number of geovisualization packages that have been implemented using PySAL as an analytical core are also demonstrated. Future plans for additional modules and enhancements are also discussed.